Sodium picosulphate
Sodium picosulfate
CAS: 10040-45-6
Molecular Formula: C18H13NO8S2.2Na
Sodium picosulphate - Names and Identifiers
| Name | Sodium picosulfate |
| Synonyms | LA 391 C13072 DA-1773 DA 1773 Sodium picosulfate Picosulfate Sodium Sodium picosulphate Sodium Picosulfate (50 mg) Sodium Picosulfate n -Hydrate 4,4'-(pyridin-2-ylmethylene)bisphenyl bis (sodiumsulphate) disodium (pyridin-2-ylmethanediyl)dibenzene-4,1-diyl disulfate 4,4'-(2-Pyridinylmethylene)bis(phenol)bis(sulfuric acid sodium) salt 4 4'-(2-PYRIDINYLMETHYLENE) BISPHENOL BI S(HYDROGEN SULFATE )(ESTER) DISODIUM SALT |
| CAS | 10040-45-6 |
| EINECS | 233-120-9 |
| InChI | InChI=1/C18H15NO8S2.2Na/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25;;/h1-12,18H,(H,20,21,22)(H,23,24,25);;/q;2*+1/p-2 |
| InChIKey | GOZDTZWAMGHLDY-UHFFFAOYSA-L |
Sodium picosulphate - Physico-chemical Properties
| Molecular Formula | C18H13NO8S2.2Na |
| Molar Mass | 481.41 |
| Melting Point | 283-286°C |
| Solubility | Freely soluble in water, slightly soluble in ethanol 96 per cent. |
| Appearance | neat |
| Color | White to Off-White |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Stability | Hygroscopic |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | Sodium Picosulfate exhibited toxic effects in cultured hepatocytes. In rapidly growing cultured rabbit hepatocytes, 800 and 1600 mg/mL resulted in dose-dependent vacuolation and steatosis and necrosis, accompanied by a decrease in mitotic activity and a slight increase in LDH values. Significant but less severe effects were observed in rat hepatocytes cultured for 4 days, whereas hepatocytes cultured for 6 to 11 days tolerated 1600 mg/kg of Sodium Picosulfate. In human hepatocyte culture medium, cell numbers were slightly lower than 800 and 1600 mg/mL, and the number of nuclear divisions was dose-dependently reduced. |
| In vivo study | Long-term treatment with Sodium picosulfate had no effect on the neuropeptide content of the rat colon. Daily dose (10 mg/kg/day) or twice weekly dose (7.5 mg/kg/day) for more than 6 months the Sodium picosulfate did not affect vasoactive intestinal peptide (VIP), growth hormone inhibitors, and the levels of substance P in the mucosa, submucosa, or muscularis epidermis. Sodium picosulfate had no significant effect on the proliferation of epithelial cells of the ileum and colon. In the 12-week study, continuous treatment with 10 mg/kg Sodium picosulfate did not affect the labeling index of Brdu (LI) in the ileum in the treatment group compared with the control group, does not cause a statistically significant increase in LI. The pattern of proliferation along the crypts did not change throughout the sodium picosulphate treatment study. Long-term treatment with Sodium picosulfate does not cause chronic changes in colonic motility in rats. Pretreatment with 10 mg/kg/day Sodium picosulfate for 23 weeks did not cause significant changes in sustained spikes (LSB) in the fasted state or after ingestion of 3G food, it is associated with a phisic contraction or LSB frequency. |
Sodium picosulphate - Risk and Safety
| HS Code | 2933399090 |
Sodium picosulphate - Reference Information
Open Data Unverified Data
| Introduction | The chemical name of sodium picosulfate (Sodiumpicosulfate) is 4,4 '(-pyridine-2-methylene-diphenyl) bisulfate sodium monohydrate, developed by DeAngeli, Italy. In May 1980, the drug was approved for marketing under the Laxoberon trade name, and has been widely used in Italy, Germany, Japan, Australia and other countries. In July 2012, the US FDA approved the listing of sodium picosulfate-magnesium oxide-citric acid oral powder (trade name: Prepopik). The drug has good clinical effects, small side effects, and high safety factor. As a toilet medicine taken once a day, sodium picosulfate has greater advantages in the treatment of constipation compared with domestic listed drugs, and the market prospect is broad. |
| pharmacological effects | studies have shown that sodium picronate has no gastrointestinal reaction, and diphenols are produced after hydrolysis of the hydrolase of the colonic flora to exert a laxative effect, among which sodium picronate exhibits a good laxative effect. The site of action of sodium picosulfate is the colon. After the enzyme hydrolysis produced by the colon flora, the active ingredient diphenols are produced, which can directly stimulate the intestinal mucosa, promote intestinal peristalsis and inhibit the absorption of water in the intestine, showing catharsis effect. Urinary excreta shows that sodium picosulfate has little absorption in the gastrointestinal tract, with little systemic effect, and its efficacy is independent of the plasma concentration of the active ingredient. |
| application | sodium pickle sulfate is a commonly used laxative in clinical practice abroad. the listed countries include Italy, Germany, Japan, Australia and other countries. Sodium picosulfate is a special laxative with a unique mode of action. It becomes a diphenol metabolite through the metabolism of the intestinal flora. This compound can make intestinal peristalsis hyperfunction, stimulate the intestinal mucosa, reduce water absorption, and produce catharsis. The catharsis effect is mild. It is suitable for various constipation, postoperative auxiliary defecation, promoting defecation after contrast agent administration, elimination of intestinal contents before surgery, and disposal before colorectal examination (endoscopy), exclusion of intestinal contents, etc. Sodium Picosulfate is a special laxative with a unique mode of action. It has a mild laxative effect on the large intestine mucosa. It can not only be used for various forms of constipation, but also can be used for hemorrhoids or anal fissure. It is also used for difficult defecation. |
| indications | sodium picosulfate is mainly used to treat various constipation clinically, such as postoperative auxiliary defecation, promoting defecation after contrast agent administration, elimination of intestinal contents before operation, pretreatment of large intestine examination (endoscope), elimination of intestinal contents, etc. |
| biological activity | Sodium Picosulfate is a kind of polyphenol irritant laxative, which can inhibit the absorption of water and electrolytes and increase their secretion. |
Last Update：2025-05-25 22:28:39
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View History
Sodium picosulphate
melting point standard benzophenone
CS-786
Sodium hydrogen sulfite
Pentanediol
TRIMESITYLPHOSPHINE
587-98-4
异丁酸
melting point standard benzophenone
CS-786
Sodium hydrogen sulfite
Pentanediol
TRIMESITYLPHOSPHINE
587-98-4
异丁酸